Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | F2R | P25116 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16756208 | 0.87 | ALOX15 (0.59) | ALOX15MEN1KMT2AHPGDHTT | |
| SCHEMBL1343624 | 0.81 | ELANE (0.46) | ALOX15MEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL31621484 | 0.81 | ELANE (0.46) | ALOX15MEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL27683008 | 0.81 | CYP2C9 (0.36) | MEN1KMT2ASMN1; SMN2GAAATM | |
| SCHEMBL15548138 | 0.80 | ALOX15 (0.53) | ALOX15MEN1KMT2AHPGDHTT | |
| SCHEMBL21598307 | 0.80 | TDP1 (0.54) | ALOX15ATMHPGDHTTKDM4E | |
| SCHEMBL7739136 | 0.80 | ALOX15 (0.49) | ALOX15KMT2AGAAHPGDHTT | |
| SCHEMBL4084650 | 0.80 | MAPT (0.54) | ALOX15MEN1KMT2ASMN1; SMN2ATM | |
| SCHEMBL15548518 | 0.80 | ALOX15 (0.53) | ALOX15MEN1KMT2ASMN1; SMN2HPGD | |
| SCHEMBL15547573 | 0.79 | ALOX15 (0.51) | ALOX15MEN1KMT2AHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | Genentech, Inc. (US) | 2017-08-16 | — | — | EP | disclosed |
| WO-2016055028-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |