Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 5/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | TTK | P33981 | 3/20 | 0.46 |
| ▸ | PIM1 | P11309 | 4/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.43 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29848857 | 1.00 | AXL (0.47) | AXLBRD4TTKPIM1CCNA2 | |
| SCHEMBL15507774 | 0.78 | TTK (0.55) | AXLTTKPIM1CCNA2CDK2 | |
| SCHEMBL30695549 | 0.76 | AXL (0.47) | AXLBRD4PIM1MAPTEPHX2 | |
| SCHEMBL12112873 | 0.75 | MAPT (0.58) | KDM4ENPC1GLAMAPTRAB9A | |
| SCHEMBL31428664 | 0.75 | GRM4 (0.65) | AXLBRD4PIM1HRH4AURKB | |
| SCHEMBL17942667 | 0.75 | BRD4 (0.47) | AXLBRD4PIM1PIM3PIM2 | |
| SCHEMBL50715 | 0.74 | KDM4E (0.66) | KDM4ENPC1GLAMAPTRAB9A | |
| SCHEMBL29398625 | 0.74 | KDM4E (0.66) | KDM4ENPC1GLAMAPTRAB9A | |
| SCHEMBL29923403 | 0.73 | PLAU (0.60) | HRH4KDM4ENPC1GLAMAPT | |
| SCHEMBL199273 | 0.73 | PLAU (0.60) | HRH4KDM4ENPC1GLAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | Genentech, Inc. (US) | 2017-08-16 | — | — | EP | disclosed |
| WO-2016055028-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |