⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17675003 | 1.00 | — | — | |
| SCHEMBL7939954 | 0.85 | CA2 (0.32) | — | |
| SCHEMBL3302336 | 0.84 | SMN1; SMN2 (0.39) | — | |
| SCHEMBL4995291 | 0.84 | SMN1; SMN2 (0.39) | — | |
| SCHEMBL9494467 | 0.82 | — | — | |
| SCHEMBL15369672 | 0.81 | CA1 (0.39) | — | |
| SCHEMBL18697005 | 0.81 | — | — | |
| SCHEMBL6994219 | 0.81 | — | — | |
| SCHEMBL838732 | 0.81 | — | — | |
| SCHEMBL6517447 | 0.80 | FAAH (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230109357-A1 | 14-MEMBERED KETOLIDES AND METHODS OF THEIR PREPARATION AND USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-04-06 | — | — | US | disclosed |
| US-11466046-B2 | 14-membered ketolides and methods of their preparation and use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2022-10-11 | — | — | US | disclosed |
| US-20200361980-A1 | 14-MEMBERED KETOLIDES AND METHODS OF THEIR PREPARATION AND USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-11-19 | — | — | US | disclosed |
| US-10633407-B2 | 14-membered ketolides and methods of their preparation and use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-04-28 | — | — | US | disclosed |
| US-20170305953-A1 | 14-MEMBERED KETOLIDES AND METHODS OF THEIR PREPARATION AND USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-10-26 | — | — | US | disclosed |
| EP-3211997-A1 | 14-MEMBERED KETOLIDES AND METHODS OF THEIR PREPARATION AND USE | President and Fellows of Harvard College (US) | 2017-09-06 | — | — | EP | disclosed |
| WO-2016057798-A1 | 14-MEMBERED KETOLIDES AND METHODS OF THEIR PREPARATION AND USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-04-14 | — | — | WO | disclosed |