Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nandrolone Phenpropionate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR known ✓ | P10275 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.86 |
| ▸ | LMNA | P02545 | 6/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.49 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.49 |
| ▸ | SHBG | P04278 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nandrolone Phenpropionate SCHEMBL8443 | 0.93 | MAPT (1.00) | MAPTLMNAALDH1A1HIF1AMCL1 | |
| Nandrolone Phenpropionate SCHEMBL29396630 | 0.93 | MAPT (1.00) | MAPTLMNAALDH1A1HIF1AMCL1 | |
| Nandrolone Phenpropionate SCHEMBL15285479 | 0.93 | MAPT (1.00) | MAPTLMNAALDH1A1HIF1AMCL1 | |
| Nandrolone Phenpropionate SCHEMBL29290732 | 0.90 | MAPT (0.93) | MAPTLMNAALDH1A1HIF1AMCL1 | |
| Nandrolone Phenpropionate SCHEMBL6151232 | 0.89 | MAPT (0.92) | MAPTLMNAALDH1A1HIF1AMCL1 | |
| Nandrolone Phenpropionate SCHEMBL28167686 | 0.86 | MAPT (0.82) | MAPTLMNAALDH1A1HIF1AMCL1 | |
| SCHEMBL11865530 | 0.85 | MAPT (0.78) | MAPTLMNAALDH1A1HIF1AMCL1 | |
| SCHEMBL20939738 | 0.85 | MAPT (0.78) | MAPTLMNAALDH1A1HIF1AMCL1 | |
| SCHEMBL11864214 | 0.83 | MAPT (0.76) | MAPTLMNAALDH1A1HIF1AMCL1 | |
| SCHEMBL21067996 | 0.83 | MAPT (0.84) | MAPTLMNAALDH1A1HIF1AMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318520-B1 | COMPOSITIONS FOR MESODERM DERIVED ISL1+ MULTIPOTENT CELLS (IMPS), EPICARDIAL PROGENITOR CELLS (EPCS) AND MULTIPOTENT CXCR4+CD56+ CELLS (C56CS) AND METHODS OF USE | THE UNIV OF GEORGIA RES FOUND INC (US) | 2017-10-11 | — | — | EP | disclosed |
| US-9732322-B2 | Compositions for mesoderm derived ISL1+ multipotent cells (IMPs), epicardial progenitor cells (EPCs) and multipotent C56C cells (C56Cs) and methods of producing and using same | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2017-08-15 | — | — | US | disclosed |
| US-20160186140-A1 | COMPOSITIONS FOR MESODERM DERIVED ISL1+ MULTIPOTENT CELLS (IMPs), EPICARDIAL PROGENITOR CELLS (EPCs) AND MULTIPOTENT C56C CELLS (C56Cs) AND METHODS OF PRODUCING AND USING SAME | UNIV GEORGIA (US) | 2016-06-30 | — | — | US | disclosed |
| US-20110305672-A1 | COMPOSITIONS FOR MESODERM DERIVED ISL1+ MULTIPOTENT CELLS (IMPs), EPICARDIAL PROGENITOR CELLS (EPCs) AND MULTIPOTENT CD56C CELLS (C56Cs) AND METHODS OF PRODUCING AND USING SAME | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2011-12-15 | — | — | US | disclosed |
| EP-2318520-A2 | COMPOSITIONS FOR MESODERM DERIVED ISL1+ MULTIPOTENT CELLS (IMPS), EPICARDIAL PROGENITOR CELLS (EPCS) AND MULTIPOTENT CXCR4+CD56+ CELLS (C56CS) AND METHODS OF USE | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2011-05-11 | — | — | EP | disclosed |
| WO-2010011352-A2 | COMPOSITIONS FOR MESODERM DERIVED ISL1+ MULTIPOTENT CELLS (IMPS), EPICARDIAL PROGENITOR CELLS (EPCS) AND MULTIPOTENT CXCR4+CD56+ CELLS (C56CS) AND METHODS OF USE | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2010-01-28 | — | — | WO | disclosed |