Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CCR1 | P32246 | 2/20 | 0.38 |
| ▸ | CCR5 | P51681 | 2/20 | 0.38 |
| ▸ | CCR8 | P51685 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17712408 | 0.77 | SMO (0.42) | SMN1; SMN2KDM4ELMNAPOLB | |
| SCHEMBL16272011 | 0.72 | GPR119 (0.45) | POLB | |
| SCHEMBL17677243 | 0.70 | SIGMAR1 (0.50) | TP53NPC1SMN1; SMN2TSHRKDM4E | |
| SCHEMBL30428092 | 0.70 | KDM4E (0.42) | TP53NPC1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL17721307 | 0.70 | KDM4E (0.42) | TP53NPC1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL10426369 | 0.70 | KDM4E (0.50) | TP53NPC1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL7591225 | 0.69 | KDM4E (0.45) | TP53NPC1SMN1; SMN2TSHRKDM4E | |
| SCHEMBL245496 | 0.69 | KDM4E (0.41) | TP53NPC1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL16272018 | 0.69 | KDM4E (0.41) | TP53NPC1SMN1; SMN2KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL17667429 | 0.68 | KDM4E (0.39) | TP53NPC1SMN1; SMN2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3006438-A1 | CYCLIC AMINOMETHYL PYRIMIDINE DERIVATIVE | Sumitomo Dainippon Pharma Co., Ltd. (JP) | 2016-04-13 | — | — | EP | disclosed |