Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL519104 | 0.90 | ADORA2A (0.40) | ADORA2AP2RX7ALOX15PDE10AHTR1A | |
| SCHEMBL518462 | 0.89 | ADORA2A (0.39) | ADORA2AP2RX7ALOX15PDE10AHTR1A | |
| SCHEMBL518934 | 0.89 | PDE10A (0.40) | ADORA2AP2RX7ALOX15PDE10AHTR1A | |
| SCHEMBL7784423 | 0.86 | ADORA2A (0.37) | ADORA2AP2RX7ALOX15PDE10AHTR1A | |
| SCHEMBL518788 | 0.85 | ADORA2A (0.36) | ADORA2AP2RX7ALOX15PDE10AHTR1A | |
| SCHEMBL518758 | 0.82 | ADORA2A (0.35) | ADORA2AP2RX7ALOX15PDE10AHTR1A | |
| SCHEMBL518759 | 0.82 | ADORA2A (0.35) | ADORA2AP2RX7ALOX15PDE10AHTR1A | |
| SCHEMBL8370043 | 0.82 | P2RX7 (0.41) | ADORA2AP2RX7ALOX15PDE10AHTR1A | |
| SCHEMBL10291032 | 0.80 | PDE10A (0.38) | ADORA2AP2RX7PDE10AHTR1ADRD2 | |
| SCHEMBL10266981 | 0.79 | ALOX15 (0.40) | ADORA2AP2RX7ALOX15HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3006031-A1 | PYRIDAZINONE COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2016-04-13 | — | — | EP | disclosed |