Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17677382 | 0.92 | PDE4B (0.47) | SMOPDE4BLMNA | |
| SCHEMBL1061487 | 0.91 | SMO (0.56) | SMOPDE4BKMT2AMEN1LMNA | |
| SCHEMBL1062446 | 0.90 | KMT2A (0.50) | SMOKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL1062520 | 0.87 | KMT2A (0.47) | SMOPDE4BKMT2AMEN1LMNA | |
| SCHEMBL1061469 | 0.87 | KMT2A (0.49) | SMOKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL1061866 | 0.84 | SMO (0.54) | SMOKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL1062667 | 0.83 | KMT2A (0.51) | KMT2AMEN1LMNAALDH1A1POLB | |
| SCHEMBL1061384 | 0.83 | LMNA (0.47) | SMOKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL1061851 | 0.83 | SMO (0.58) | SMOPDE4B | |
| SCHEMBL1062124 | 0.81 | SMO (0.57) | SMOKMT2AMEN1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247588-B1 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2016-04-13 | — | — | EP | disclosed |