SCHEMBL1767745

SCHEMBL1767745

CCOCc1nc2nc(N)[nH]c(=O)c2[nH]1

nearest known ligand 0.56

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PNP P00491 6/20 0.56
KDM4E B2RXH2 1/20 0.43
MEN1 O00255 1/20 0.43
ALDH1A1 P00352 1/20 0.43
MAPT P10636 1/20 0.43
THRB P10828 1/20 0.43
HPGD P15428 1/20 0.43
KMT2A Q03164 1/20 0.43
HSD17B10 Q99714 1/20 0.43
FGFR1 P11362 2/20 0.42
FGFR2 P21802 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10421279 0.90 PNP (0.54) PNPKDM4EMEN1ALDH1A1MAPT
SCHEMBL2343355 0.84 PNP (0.59) PNPKDM4EMEN1ALDH1A1MAPT
SCHEMBL37957 0.82 PNP (0.53) PNPKDM4EMEN1ALDH1A1MAPT
SCHEMBL874735 0.82 PNP (0.66) PNPKDM4EMEN1ALDH1A1MAPT
SCHEMBL667795 0.80 PNP (0.61) PNPKDM4EMEN1ALDH1A1MAPT
SCHEMBL5935062 0.79 PNP (0.70) PNPKDM4EMEN1ALDH1A1MAPT
SCHEMBL9960811 0.79 PNP (0.71) PNPKDM4EMEN1ALDH1A1MAPT
SCHEMBL4730342 0.78 FGFR1 (0.34) PNPFGFR1FGFR2
SCHEMBL6268782 0.77 PNP (0.50) PNPKDM4EMEN1ALDH1A1MAPT
SCHEMBL6272728 0.77 PNP (0.58) PNPKDM4EMEN1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021222988-A1 CELL ENTRY-MODULATING AGENTS AND USES THEREFOR GRIFFITH UNIVERSITY (AU) 2021-11-11 WO disclosed
WO-2012078637-A2 COMPOSITION AND METHOD FOR OLIGONUCLEOTIDE DELIVERY IMMUNE DISEASE INSTITUTE, INC. (US) 2012-06-14 WO disclosed
WO-2011056630-A2 SMALL MOLECULE INHIBITORS OF HEPATITIS C VIRUS TRUSTEES OF BOSTON UNIVERSITY (US) 2011-05-12 WO disclosed
EP-2205294-A2 IMMOBILIZED BIOLOGICALLY ACTIVE ENTITIES HAVING A HIGH DEGREE OF BIOLOGICAL ACTIVITY Gore Enterprise Holdings, Inc. (US) 2010-07-14 EP disclosed
WO-2009064372-A2 IMMOBILIZED BIOLOGICALLY ACTIVE ENTITIES HAVING A HIGH DEGREE OF BIOLOGICAL ACTIVITY GORE ENTERPRISE HOLDINGS, INC. (US) 2009-05-22 WO disclosed