SCHEMBL37957

SCHEMBL37957

Nc1nc2nc(COCCO)[nH]c2c(=O)[nH]1

nearest known ligand 0.53

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PNP P00491 9/20 0.53
HSD17B10 Q99714 2/20 0.43
USP2 O75604 1/20 0.43
TSHR P16473 1/20 0.43
EDNRA P25101 1/20 0.43
HTR2A P28223 1/20 0.43
RECQL P46063 1/20 0.43
BLM P54132 1/20 0.43
HBB P68871 1/20 0.43
KDM4E B2RXH2 1/20 0.41
MEN1 O00255 1/20 0.41
ALDH1A1 P00352 1/20 0.41
MAPT P10636 1/20 0.41
THRB P10828 1/20 0.41
HPGD P15428 1/20 0.41
KMT2A Q03164 1/20 0.41
FGFR1 P11362 1/20 0.40
FGFR2 P21802 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2346356 0.87 PNP (0.51) PNPHSD17B10USP2TSHREDNRA
SCHEMBL10421279 0.87 PNP (0.54) PNPHSD17B10KDM4EMEN1ALDH1A1
SCHEMBL1767745 0.82 PNP (0.56) PNPHSD17B10KDM4EMEN1ALDH1A1
SCHEMBL8397615 0.82 PNP (0.54) PNP
SCHEMBL350396 0.80 PNP (0.61) PNPHSD17B10KDM4EMEN1ALDH1A1
SCHEMBL14079841 0.80 PNP (0.66) PNPHSD17B10KDM4EMEN1ALDH1A1
SCHEMBL2343355 0.79 PNP (0.59) PNPHSD17B10KDM4EMEN1ALDH1A1
SCHEMBL4908015 0.79 PNP (0.51) PNPHSD17B10BLMKDM4EMEN1
SCHEMBL10711111 0.77 PNP (0.51) PNPHSD17B10USP2TSHREDNRA
SCHEMBL9960811 0.76 PNP (0.71) PNPHSD17B10KDM4EMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 252 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260083840-A1 METHODS FOR ABLATING MYELOID DERIVED SUPPRESSOR CELLS USING NEO-201 ANTIBODY PREC BIOLOGICS INC (US) 2026-03-26 US claimed
EP-4499710-A1 METHODS FOR ABLATING MYELOID DERIVED SUPPRESSOR CELLS USING NEO-201 ANTIBODY Precision Biologics, Inc. (US) 2025-02-05 EP claimed
US-20240400714-A1 METHODS AND COMPOSITIONS FOR TARGETING TREG CELLS PREC BIOLOGICS INC (US) 2024-12-05 US claimed
US-20240384003-A1 METHODS AND COMPOSITIONS FOR TREATING HEMATOLOGICAL MALIGNANCIES PREC BIOLOGICS INC (US) 2024-11-21 US claimed
CN-112041343-B Methods and compositions for targeting Treg cells 精密生物制品股份有限公司 2024-08-30 CN claimed
CN-118234748-A Methods and compositions for treating hematological malignancies 精密生物制品股份有限公司 2024-06-21 CN claimed
EP-4352103-A2 METHODS AND COMPOSITIONS FOR TREATING HEMATOLOGICAL MALIGNANCIES Precision Biologics, Inc. (US) 2024-04-17 EP claimed
WO-2023225608-A1 METHODS FOR ABLATING MYELOID DERIVED SUPPRESSOR CELLS USING NEO-201 ANTIBODY PRECISION BIOLOGICS, INC. (US) 2023-11-23 WO claimed
WO-2022246066-A2 METHODS AND COMPOSITIONS FOR TREATING HEMATOLOGICAL MALIGNANCIES PRECISION BIOLOGICS, INC. (US) 2022-11-24 WO claimed
US-20210002383-A1 METHODS AND COMPOSITIONS FOR TARGETING TREG CELLS PREC BIOLOGICS INC (US) 2021-01-07 US claimed
US-20140219957-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF IMMUNE DISORDERS BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) 2014-08-07 US claimed
WO-2013185055-A1 METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1 BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) 2013-12-12 WO claimed
WO-2012162698-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF IMMUNE DISORDERS BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) 2012-11-29 WO claimed
US-20100144618-A1 Compositions containing an intestinal trefoil peptide and a mucoadhesive PODOLSKY DANIEL K 2010-06-10 US claimed
US-20060189526-A1 COMPOSITIONS CONTAINING AN INTESTINAL TREFOIL PEPTIDE AND A MUCOADHESIVE THE GENERAL HOSPITAL CORPORATION 2006-08-24 US claimed
US-RE38341-E1 Method for electrokinetic delivery of medicaments BIOPHORETIC THERAPEUTIC SYSTEMS, LLC 2003-12-09 US claimed
US-5879323-A IONOPHORETIC TRANSDERMAL DELIVERY OF A 2-HYDROXYETHOXY(METHYL)GUANINE INTO TISSUES OVERLYING MUCOCUTANEOUS HERPES TYPE I AND TYPE II INFECTIONS THE APS ORGANIZATION, LLP (US) 1999-03-09 US claimed
EP-0531452-A4 SYNTHESIS OF GLYCEROL DI- AND TRIPHOSPHATE DERIVATIVES 1993-06-09 EP claimed
EP-0531452-A1 SYNTHESIS OF GLYCEROL DI- AND TRIPHOSPHATE DERIVATIVES NeXstar Pharmaceuticals, Inc. (US) 1993-03-17 EP claimed
WO-1991018914-A1 SYNTHESIS OF GLYCEROL DI- AND TRIPHOSPHATE DERIVATIVES VICAL, INC. (US) 1991-12-12 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260083840-A1 METHODS FOR ABLATING MYELOID DERIVED SUPPRESSOR CELLS USING NEO-201 ANTIBODY CD47, SIGLEC9, LGALS1 PNP 1734/4885HSD17B10 4695/4885USP2 1667/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.