Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.31 |
| ▸ | CDK9 | P50750 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1767952 | 0.72 | HRH4 (0.41) | HRH4 | |
| SCHEMBL2955427 | 0.71 | HRH3 (0.49) | TSHRKDM4E | |
| SCHEMBL1767772 | 0.69 | HMGCR (0.35) | KDM4ECCNT1CDK9 | |
| SCHEMBL5021906 | 0.68 | MAPT (0.35) | PPARDTSHRCCNT1CDK9 | |
| SCHEMBL2703616 | 0.68 | PPARD (0.39) | PPARDTSHR | |
| SCHEMBL13640341 | 0.68 | MAPT (0.35) | PPARDTSHRCCNT1CDK9 | |
| SCHEMBL1767853 | 0.67 | HRH4 (0.34) | HRH4 | |
| Dimethylamine SCHEMBL9053689 | 0.66 | HRH4 (0.45) | HRH4 | |
| SCHEMBL31744500 | 0.66 | PPARD (0.44) | PPARDTSHR | |
| SCHEMBL1107416 | 0.66 | SMN1; SMN2 (0.43) | PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2504330-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011063272-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-05-26 | — | — | WO | disclosed |