Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | SELE | P16581 | 1/20 | 0.31 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.31 |
| ▸ | PRKCI | P41743 | 1/20 | 0.30 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1767952 | 0.92 | HRH4 (0.41) | HRH4CYP1A2POLBMAP4K4NOS3 | |
| SCHEMBL5239757 | 0.81 | CYP1A2 (0.41) | HRH4CYP1A2POLBMAP4K4 | |
| SCHEMBL4872734 | 0.80 | CYP1A2 (0.37) | HRH4CYP1A2POLBMAP4K4NOS3 | |
| SCHEMBL805489 | 0.77 | — | — | |
| SCHEMBL25986789 | 0.77 | HRH4 (0.34) | HRH4CYP1A2POLBAAK1 | |
| SCHEMBL20801088 | 0.77 | NOS3 (0.37) | HRH4CYP1A2POLBNOS3NOS2 | |
| SCHEMBL1767853 | 0.77 | HRH4 (0.34) | HRH4CYP1A2POLBSELEVCAM1 | |
| SCHEMBL23015721 | 0.77 | HRH4 (0.35) | HRH4MAP4K4AAK1 | |
| SCHEMBL12311620 | 0.75 | — | — | |
| SCHEMBL792959 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996000248-A1 | WATER MISCIBLE NON-HYDROLYZABLE CROSS-LINKERS AND HIGH REFRACTIVE INDEX HYDROGELS PREPARED THEREWITH | KABI PHARMACIA OPHTHALMICS, INC. (US) | 1996-01-04 | — | — | WO | disclosed |
| US-5439950-A | Intraocular lenses | KABI PHARMACIA OPHTHALMICS, INC. (US) | 1995-08-08 | — | — | US | disclosed |