Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 9/20 | 0.56 |
| ▸ | CES1 | P23141 | 3/20 | 0.56 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.56 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29145018 | 0.87 | FAAH (0.57) | FAAHCES1DAGLA | |
| SCHEMBL19890145 | 0.85 | FAAH (0.54) | FAAHCES1DAGLA | |
| SCHEMBL29037513 | 0.82 | IKBKB (0.62) | IKBKBTLR8 | |
| SCHEMBL7170901 | 0.77 | SOAT1 (0.53) | FAAHCES1DAGLA | |
| SCHEMBL1767937 | 0.77 | TLR8 (0.82) | TLR8 | |
| SCHEMBL3263294 | 0.76 | SMN1; SMN2 (0.52) | FAAHCES1DAGLATLR8 | |
| SCHEMBL19876966 | 0.76 | FAAH (0.43) | FAAHCES1DAGLATLR8 | |
| SCHEMBL25383771 | 0.75 | FAAH (0.57) | FAAHCES1DAGLA | |
| SCHEMBL19890270 | 0.75 | FAAH (0.42) | FAAHCES1DAGLATLR8 | |
| SCHEMBL28060768 | 0.74 | FAAH (0.47) | FAAHCES1DAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2504330-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011063272-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-05-26 | — | — | WO | disclosed |