Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.43 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19876966 | 0.80 | FAAH (0.43) | SMN1; SMN2ALDH1A1HTTTLR8FAAH | |
| SCHEMBL19890270 | 0.79 | FAAH (0.42) | SMN1; SMN2KDM4EALDH1A1HTTTLR8 | |
| SCHEMBL19876790 | 0.78 | NPSR1 (0.47) | SMN1; SMN2KDM4EALDH1A1HTTATM | |
| SCHEMBL19876763 | 0.77 | KDM4E (0.49) | KDM4EALDH1A1HTTTLR8FAAH | |
| SCHEMBL29145018 | 0.77 | FAAH (0.57) | FAAHDAGLACES1 | |
| SCHEMBL19876762 | 0.77 | KDM4E (0.49) | KDM4EALDH1A1HTTTLR8FAAH | |
| SCHEMBL19890145 | 0.77 | FAAH (0.54) | FAAHDAGLACES1 | |
| SCHEMBL1767933 | 0.76 | FAAH (0.56) | TLR8FAAHDAGLACES1 | |
| SCHEMBL3144090 | 0.76 | KDM4E (0.55) | SMN1; SMN2KDM4EALDH1A1HTTATM | |
| SCHEMBL287359 | 0.76 | OXER1 (0.49) | KDM4EALDH1A1HTTTLR8DAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140221371-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-08-07 | — | — | US | claimed |
| US-20100041698-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2010-02-18 | — | — | US | claimed |
| US-11161824-B2 | Heterocyclic lipoxin analogs and uses thereof | UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN (IE) | 2021-11-02 | — | — | US | disclosed |
| US-11161824-B2 | Heterocyclic lipoxin analogs and uses thereof | UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN (IE) | 2021-11-02 | — | — | US | disclosed |
| EP-3500559-B1 | HETEROCYCLIC LIPOXIN ANALOGS AND USES THEROF | UNIV COLLEGE DUBLIN NAT UNIV IRELAND DUBLIN (IE) | 2021-06-16 | — | — | EP | disclosed |
| EP-3500559-B1 | HETEROCYCLIC LIPOXIN ANALOGS AND USES THEROF | UNIV COLLEGE DUBLIN NAT UNIV IRELAND DUBLIN (IE) | 2021-06-16 | — | — | EP | disclosed |
| US-20210053927-A1 | Heterocyclic Lipoxin Analogs and Uses Thereof | UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN (IE) | 2021-02-25 | — | — | US | disclosed |
| US-20210053927-A1 | Heterocyclic Lipoxin Analogs and Uses Thereof | UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN (IE) | 2021-02-25 | — | — | US | disclosed |
| EP-3500559-A1 | HETEROCYCLIC LIPOXON ANALOGS AND USES THEROF | University College Dublin (IE) | 2019-06-26 | — | — | EP | disclosed |
| WO-2018033642-A9 | HETEROCYCLIC LIPOXIN ANALOGS AND USES THEREOF | UNIVERSITY COLLEGE DUBLIN (IE) | 2018-10-18 | — | — | WO | disclosed |
| WO-2018033642-A1 | HETEROCYCLIC LIPXON ANALOGS AND USES THEROF | UNIVERSITY COLLEGE DUBLIN (IE) | 2018-02-22 | — | — | WO | disclosed |
| WO-2018033642-A1 | HETEROCYCLIC LIPXON ANALOGS AND USES THEROF | UNIVERSITY COLLEGE DUBLIN (IE) | 2018-02-22 | — | — | WO | disclosed |
| US-20140221371-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-08-07 | — | — | US | disclosed |
| US-20100041698-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221371-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | HTR5A, HTR1A, HTR2C | SMN1; SMN2 1722/4885KDM4E 3028/4885ALDH1A1 1897/4885 |
| US-11161824-B2 | Heterocyclic lipoxin analogs and uses thereof | LTB4R2, ALOX12, ALOX15B | SMN1; SMN2 3676/4885KDM4E 1736/4885ALDH1A1 1306/4885 |
| US-20100041698-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | HTR5A, HTR1A, HTR2C | SMN1; SMN2 1722/4885KDM4E 3028/4885ALDH1A1 1897/4885 |
| US-20210053927-A1 | Heterocyclic Lipoxin Analogs and Uses Thereof | LTB4R2, ALOX12, ALOX15B | SMN1; SMN2 3676/4885KDM4E 1736/4885ALDH1A1 1306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.