Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.42 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19879566 | 0.87 | KDM4E (0.49) | KMT2AKDM4EPIK3CAMAP3K12ALDH1A1 | |
| SCHEMBL19880894 | 0.74 | KMT2A (0.47) | KMT2AKDM4EPIK3CAMAP3K12ALDH1A1 | |
| SCHEMBL21154548 | 0.72 | CYP2C19 (0.42) | KMT2AKDM4EPIK3CACNR2ALDH1A1 | |
| SCHEMBL31678599 | 0.70 | ALDH1A1 (0.47) | KMT2AKDM4EPIK3CAMAP3K12CNR2 | |
| SCHEMBL38653595 | 0.69 | SOS1 (0.43) | KMT2AKDM4EALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL9003193 | 0.67 | KMT2A (0.76) | KMT2AKDM4EPIK3CAMAP3K12ALDH1A1 | |
| SCHEMBL15645517 | 0.66 | AOC3 (0.51) | KDM4EPIK3CAALDH1A1MAPTMAPK1 | |
| SCHEMBL11050768 | 0.66 | KDM4E (0.60) | KDM4EPIK3CAALDH1A1CYP1A2USP2 | |
| SCHEMBL1711396 | 0.66 | POLB (0.51) | KDM4EPIK3CAALDH1A1CYP1A2USP2 | |
| SCHEMBL30287040 | 0.66 | CYP1A2 (0.49) | KMT2AKDM4EPIK3CAMAP3K12ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160102094-A1 | Azaquinazoline Inhibitors of Atypical Protein Kinase C | IGNYTA, INC. (US) | 2016-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160102094-A1 | Azaquinazoline Inhibitors of Atypical Protein Kinase C | PRKCQ, PRKCZ, PRKCE | KMT2A 1166/4885KDM4E 936/4885PIK3CA 553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.