Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 9/20 | 0.41 |
| ▸ | MAP4K3 | Q8IVH8 | 2/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.37 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17681017 | 0.81 | MAP4K4 (0.47) | MAP4K4BRD4CREBBPCNR2MAP4K3 | |
| SCHEMBL19446090 | 0.80 | CNR2 (0.40) | CNR2CNR1TRPC6 | |
| SCHEMBL15880738 | 0.78 | MAP4K4 (0.47) | MAP4K4BRD4CREBBPCNR2MAP4K3 | |
| SCHEMBL19531672 | 0.77 | DHFR (0.46) | MAP4K4BRD4CREBBPCNR2MAP4K3 | |
| SCHEMBL91322 | 0.76 | PTGS2 (0.48) | DHFR | |
| SCHEMBL15609364 | 0.74 | MAP4K3 (0.50) | MAP4K4MAP4K3 | |
| SCHEMBL19673294 | 0.73 | BRD4 (0.39) | BRD4CNR2 | |
| SCHEMBL18118645 | 0.73 | EP300 (0.40) | CNR2 | |
| SCHEMBL18400077 | 0.72 | SCN9A (0.38) | CNR2CNR1 | |
| SCHEMBL19446253 | 0.71 | MAP3K12 (0.46) | MAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055028-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |