Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 6/20 | 0.64 |
| ▸ | BRD4 | O60885 | 6/20 | 0.64 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 3/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22368749 | 0.90 | BRD4 (0.61) | CREBBPBRD4CRBNIKZF3CYP19A1 | |
| SCHEMBL22369127 | 0.86 | BRD4 (0.53) | CREBBPBRD4PTGER1TNKS2IDO1 | |
| SCHEMBL17680971 | 0.82 | BRD4 (0.67) | CREBBPBRD4CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL17680783 | 0.78 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL18050048 | 0.76 | BRD4 (0.55) | CREBBPBRD4CRBNIKZF3CYP19A1 | |
| SCHEMBL17680903 | 0.74 | CREBBP (0.64) | CREBBPBRD4CRBNMAOAMAOB | |
| SCHEMBL22369180 | 0.73 | CREBBP (0.66) | CREBBPBRD4 | |
| SCHEMBL31443854 | 0.72 | MAPT (0.50) | CREBBPBRD4MAOAMAOBHTT | |
| SCHEMBL4716831 | 0.72 | MAPT (0.50) | CREBBPBRD4MAOAMAOBHTT | |
| SCHEMBL22368660 | 0.72 | CREBBP (0.60) | CREBBPBRD4CRBNMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-08-26 | — | — | EP | disclosed |
| WO-2016055028-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |