Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 6/20 | 0.67 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.67 |
| ▸ | MAOB | P27338 | 7/20 | 0.52 |
| ▸ | MAOA | P21397 | 5/20 | 0.52 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17680672 | 0.82 | CREBBP (0.64) | BRD4CREBBPMAOBMAOATNKS2 | |
| SCHEMBL22369180 | 0.81 | CREBBP (0.66) | BRD4CREBBP | |
| SCHEMBL17680707 | 0.80 | CREBBP (1.00) | BRD4CREBBP | |
| SCHEMBL22368749 | 0.79 | BRD4 (0.61) | BRD4CREBBPMAOBMAOATNKS2 | |
| SCHEMBL22368732 | 0.78 | MAOB (0.70) | CREBBPMAOBMAOA | |
| SCHEMBL30901162 | 0.78 | MAOB (0.70) | CREBBPMAOBMAOA | |
| SCHEMBL29262890 | 0.78 | MAOB (0.70) | CREBBPMAOBMAOA | |
| SCHEMBL17680875 | 0.73 | CREBBP (0.64) | BRD4CREBBPMAOB | |
| SCHEMBL22368880 | 0.72 | CREBBP (0.64) | BRD4CREBBP | |
| SCHEMBL22368795 | 0.72 | CREBBP (0.44) | BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-08-26 | — | — | EP | disclosed |
| WO-2016055028-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |