Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 3/20 | 0.64 |
| ▸ | BRD4 | O60885 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | MMP12 | P39900 | 2/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22369307 | 0.87 | BRD4 (0.54) | CREBBPBRD4ALDH1A1TDP1MAPK1 | |
| SCHEMBL17673280 | 0.78 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL22368749 | 0.78 | BRD4 (0.61) | CREBBPBRD4ALDH1A1TDP1MAPK1 | |
| SCHEMBL21027971 | 0.74 | BRD4 (0.56) | CREBBPBRD4ALDH1A1TDP1MAPK1 | |
| SCHEMBL22368804 | 0.74 | CREBBP (0.62) | CREBBPBRD4ALDH1A1 | |
| SCHEMBL17680672 | 0.74 | CREBBP (0.64) | CREBBPBRD4CRBNMAOAMAOB | |
| SCHEMBL17680982 | 0.74 | CREBBP (0.64) | CREBBPBRD4ALDH1A1 | |
| SCHEMBL17680977 | 0.72 | CREBBP (0.68) | CREBBPBRD4ALDH1A1TSHR | |
| SCHEMBL22368660 | 0.72 | CREBBP (0.60) | CREBBPBRD4NPC1DDB1CRBN | |
| SCHEMBL50441 | 0.71 | ALDH1A1 (0.89) | ALDH1A1TDP1MAPK1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055028-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |