Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 6/20 | 0.67 |
| ▸ | CREBBP | Q92793 | 6/20 | 0.67 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RELA | Q04206 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22368917 | 0.85 | CREBBP (0.62) | BRD4CREBBPMAPTLMNARAB9A | |
| SCHEMBL19518157 | 0.81 | CREBBP (1.00) | BRD4CREBBPDYRK1ADYRK1BCLK1 | |
| SCHEMBL17680589 | 0.81 | CREBBP (1.00) | BRD4CREBBPDYRK1ADYRK1BCLK1 | |
| SCHEMBL17673132 | 0.81 | CREBBP (1.00) | BRD4CREBBPDYRK1ADYRK1BCLK1 | |
| SCHEMBL17680921 | 0.80 | CREBBP (0.67) | BRD4CREBBPMAPTRELAKDM4E | |
| SCHEMBL22368874 | 0.74 | BRD4 (0.67) | BRD4CREBBPDYRK1ADYRK1BMAPT | |
| SCHEMBL17680611 | 0.72 | CREBBP (1.00) | BRD4CREBBP | |
| SCHEMBL4484367 | 0.70 | NPC1 (0.41) | BRD4CREBBPMAPT | |
| SCHEMBL15964658 | 0.70 | CREBBP (0.55) | BRD4CREBBPMAPTKDM4ERAB9A | |
| SCHEMBL15964652 | 0.70 | PDE3B (0.50) | DYRK1ADYRK1BMAPTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-08-26 | — | — | EP | disclosed |
| WO-2016055028-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |