Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15964644 | 0.88 | ALDH1A1 (0.49) | PDE3BPDE3AMAOAMAOBDRD4 | |
| SCHEMBL30871998 | 0.84 | DRD4 (0.59) | PDE3BPDE3AMAOAMAOBDRD4 | |
| SCHEMBL1494348 | 0.84 | DRD4 (0.59) | PDE3BPDE3AMAOAMAOBDRD4 | |
| SCHEMBL23189095 | 0.84 | BRD4 (0.45) | PDE3BPDE3AMAOAMAOBDRD2 | |
| SCHEMBL15964938 | 0.81 | BRD4 (0.40) | PDE3BPDE3AMAOBDRD4DRD3 | |
| SCHEMBL22368731 | 0.81 | BRD4 (0.63) | PDE3BPDE3AMAOAMAOBSMN1; SMN2 | |
| SCHEMBL12060952 | 0.80 | MMP12 (0.53) | PDE3BPDE3ADRD4DRD3ALDH1A1 | |
| SCHEMBL30076371 | 0.78 | TP53 (0.45) | SMN1; SMN2ALDH1A1POLBMAPTPKM | |
| SCHEMBL22368809 | 0.78 | BRD4 (0.63) | PDE3BPDE3AMAOAMAOBSMN1; SMN2 | |
| SCHEMBL22369086 | 0.77 | MAOB (0.65) | MAOAMAOBSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |
| WO-2014125444-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2014-08-21 | — | — | WO | disclosed |