Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19518336 | 0.85 | KDM4E (0.41) | L3MBTL1POLBKDM4ECTDSP1TDP1 | |
| SCHEMBL17673210 | 0.85 | KDM4E (0.41) | L3MBTL1POLBKDM4ECTDSP1TDP1 | |
| SCHEMBL17680663 | 0.84 | PIM1 (0.38) | L3MBTL1POLBKDM4EALDH1A1CYP1A2 | |
| SCHEMBL17680858 | 0.84 | KMT2A (0.38) | POLBALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL17680841 | 0.76 | CYP1A2 (0.44) | L3MBTL1POLBTDP1ALDH1A1CYP1A2 | |
| SCHEMBL17680928 | 0.69 | ALDH1A1 (0.43) | L3MBTL1POLBALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL17673268 | 0.69 | PIM1 (0.40) | L3MBTL1POLBKDM4EALDH1A1CYP1A2 | |
| SCHEMBL19518192 | 0.69 | PIM1 (0.40) | L3MBTL1POLBKDM4EALDH1A1CYP1A2 | |
| SCHEMBL19518201 | 0.69 | KMT2A (0.38) | POLBALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL17673305 | 0.69 | KMT2A (0.38) | POLBALDH1A1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055028-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |