Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 11/20 | 0.62 |
| ▸ | BRD4 | O60885 | 9/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15964658 | 0.77 | CREBBP (0.55) | CREBBPBRD4ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL17673128 | 0.77 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL22369211 | 0.76 | BRD4 (0.64) | CREBBPBRD4ALDH1A1MEN1KMT2A | |
| SCHEMBL27051273 | 0.73 | CREBBP (0.38) | CREBBPBRD4ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL19539048 | 0.73 | CREBBP (0.65) | CREBBPBRD4ALDH1A1MEN1KMT2A | |
| SCHEMBL27060152 | 0.72 | BRD4 (0.39) | CREBBPBRD4MEN1KMT2ALMNA | |
| SCHEMBL4484367 | 0.71 | NPC1 (0.41) | CREBBPBRD4MEN1KMT2AADRA1A | |
| SCHEMBL22369151 | 0.70 | CREBBP (0.67) | CREBBPBRD4ALDH1A1LMNA | |
| SCHEMBL19539069 | 0.69 | CREBBP (0.69) | CREBBPBRD4 | |
| SCHEMBL22368752 | 0.69 | CREBBP (0.45) | CREBBPBRD4NPC1MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-08-26 | — | — | EP | disclosed |
| WO-2016055028-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |
| US-20150147457-A1 | ISOTOPICALLY MODIFIED COMPOUNDS AND THEIR USE AS FOOD SUPPLEMENTS | BIOJIVA LLC | 2015-05-28 | — | — | US | disclosed |