Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 14/20 | 0.45 |
| ▸ | BRD4 | O60885 | 11/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | OGA | O60502 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22368946 | 0.82 | CREBBP (0.57) | CREBBPBRD4NPC1MAPK13MAPK12 | |
| SCHEMBL19539148 | 0.79 | CREBBP (0.65) | CREBBPBRD4NPC1MAPK13MAPK12 | |
| SCHEMBL15964658 | 0.77 | CREBBP (0.55) | CREBBPBRD4NPC1MAPK13MAPK12 | |
| SCHEMBL19531721 | 0.75 | CREBBP (0.77) | CREBBPBRD4 | |
| SCHEMBL27060152 | 0.75 | BRD4 (0.39) | CREBBPBRD4NPC1MAPK13MAPK12 | |
| SCHEMBL4484367 | 0.74 | NPC1 (0.41) | CREBBPBRD4NPC1MAPK13MAPK12 | |
| SCHEMBL27051273 | 0.74 | CREBBP (0.38) | CREBBPBRD4NPC1MAPK13MAPK12 | |
| SCHEMBL17680916 | 0.69 | CREBBP (0.62) | CREBBPBRD4NPC1MAPK13MAPK12 | |
| SCHEMBL22368917 | 0.68 | CREBBP (0.62) | CREBBPBRD4NPC1MAPK13MAPK12 | |
| SCHEMBL30752987 | 0.67 | CREBBP (0.43) | CREBBPBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-08-26 | — | — | EP | disclosed |