Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 6/20 | 0.68 |
| ▸ | BRD4 | O60885 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | KCNA5 | P22460 | 11/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22368720 | 0.89 | CREBBP (0.71) | CREBBPBRD4KDM4EALDH1A1LMNA | |
| SCHEMBL17680982 | 0.85 | CREBBP (0.64) | CREBBPBRD4ALDH1A1 | |
| SCHEMBL22360964 | 0.81 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL17680765 | 0.81 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL22368935 | 0.78 | CREBBP (0.76) | CREBBPBRD4KDM4EALDH1A1LMNA | |
| SCHEMBL22368804 | 0.77 | CREBBP (0.62) | CREBBPBRD4ALDH1A1 | |
| SCHEMBL17680903 | 0.72 | CREBBP (0.64) | CREBBPBRD4ALDH1A1TSHR | |
| SCHEMBL17680894 | 0.70 | CREBBP (0.70) | CREBBPBRD4KCNK3 | |
| SCHEMBL22368923 | 0.70 | CREBBP (0.43) | CREBBPBRD4 | |
| SCHEMBL22368638 | 0.70 | CREBBP (0.67) | CREBBPBRD4ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055028-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |