SCHEMBL176812

SCHEMBL176812

Nc1ccccc1C(=O)CCC(N)C(=O)O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.48
ALOX15 P16050 1/20 0.48
BLM P54132 1/20 0.48
PMP22 Q01453 1/20 0.48
LTA4H P09960 3/20 0.48
KYNU Q16719 2/20 0.46
KIF11 P52732 4/20 0.46
GRM8 O00222 1/20 0.46
GRM6 O15303 1/20 0.46
GRIN2D O15399 1/20 0.46
GRIN3B O60391 1/20 0.46
GSR P00390 1/20 0.46
CYP1A2 P05177 1/20 0.46
GRIK1 P39086 1/20 0.46
GRM5 P41594 1/20 0.46
GRIA1 P42261 1/20 0.46
GRIA2 P42262 1/20 0.46
GRIA3 P42263 1/20 0.46
SLC1A3 P43003 1/20 0.46
SLC1A2 P43004 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Glutamine SCHEMBL27980123 0.84 KMT2A (0.59) KMT2AALOX15BLMPMP22LTA4H
D-Glutamate SCHEMBL28908581 0.84 GRM8 (0.56) KMT2AALOX15BLMPMP22LTA4H
L-Kynurenine SCHEMBL29415716 0.83 KDM4E (0.64) KYNUGRIK1SLC1A3SLC1A2SLC1A1
Kynurenine SCHEMBL20874 0.83 KDM4E (0.64) KYNUGRIK1SLC1A3SLC1A2SLC1A1
Kynurenine SCHEMBL29349989 0.83 KDM4E (0.64) KYNUGRIK1SLC1A3SLC1A2SLC1A1
Kynurenine SCHEMBL288988 0.83 KDM4E (0.64) KYNUGRIK1SLC1A3SLC1A2SLC1A1
L-Kynurenine SCHEMBL288989 0.83 KDM4E (0.64) KYNUGRIK1SLC1A3SLC1A2SLC1A1
Kynurenine SCHEMBL2181581 0.83 KDM4E (0.64) KYNUGRIK1SLC1A3SLC1A2SLC1A1
L-Kynurenine SCHEMBL13969610 0.83 KDM4E (0.64) KYNUGRIK1SLC1A3SLC1A2SLC1A1
L-Kynurenine SCHEMBL20875 0.83 KDM4E (0.64) KYNUGRIK1SLC1A3SLC1A2SLC1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9611502-B2 Method for simultaneously measuring activity of various enzymes by using multi-wavelength absorption single channel CHONGQING MEDICAL UNIVERSITY (CN) 2017-04-04 US disclosed
US-20150225764-A1 METHOD FOR SIMULTANEOUSLY MEASURING ACTIVITY OF VARIOUS ENZYMES BY USING MULTI-WAVELENGTH ABSORPTION SINGLE CHANNEL CHONGQING MEDICAL UNIVERSITY (CN) 2015-08-13 US disclosed
US-9000208-B2 Glutamate derivatives or salts thereof AJINOMOTO CO., INC. (JP) 2015-04-07 US disclosed
US-8877739-B2 Prophylactic agent or therapeutic agent for diabetes or obesity AJINOMOTO CO., INC. (JP) 2014-11-04 US disclosed
US-20130102570-A1 PROPHYLACTIC AGENT OR THERAPEUTIC AGENT FOR DIABETES OR OBESITY AJINOMOTO CO., INC. (JP) 2013-04-25 US disclosed
EP-2554165-A1 PROPHYLACTIC AGENT OR THERAPEUTIC AGENT FOR DIABETES OR OBESITY Ajinomoto Co., Inc. (JP) 2013-02-06 EP disclosed
EP-2551262-A1 GLUTAMATE DERIVATIVES OR SALTS THEREOF Ajinomoto Co., Inc. (JP) 2013-01-30 EP disclosed
US-20130017603-A1 GLUTAMATE DERIVATIVES OR SALTS THEREOF AJINOMOTO CO., INC. (JP) 2013-01-17 US disclosed
EP-2345636-A1 CASR AGONIST Ajinomoto Co., Inc. (JP) 2011-07-20 EP disclosed
US-4603107-A SIMUTANEOUSLY REACTING WITH GLUTAMYLARYLAMIDE, THEN OXIDIZER AND COUPLING AGENT TO GIVE COLORED COMPOUND BOEHRINGER MANNHEIM GMBH (DE) 1986-07-29 US disclosed
EP-0103823-A2 Method and reagent for the determination of gamma-glutamyltransferase Roche Diagnostics GmbH (DE) 1984-03-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130017603-A1 GLUTAMATE DERIVATIVES OR SALTS THEREOF CASR, GIPR, GRPR KMT2A 3666/4885ALOX15 1607/4885BLM 4214/4885
US-20130102570-A1 PROPHYLACTIC AGENT OR THERAPEUTIC AGENT FOR DIABETES OR OBESITY GPR119, GIPR, CASR KMT2A 4292/4885ALOX15 953/4885BLM 3913/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.