Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | DHFR | P00374 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NQO1 | P15559 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL131598 | 0.83 | TP53 (0.59) | CYP3A4TP53CHRM2CHRM1CHRM3 | |
| SCHEMBL31061915 | 0.83 | TP53 (0.59) | CYP3A4TP53CHRM2CHRM1CHRM3 | |
| SCHEMBL5247746 | 0.83 | TP53 (0.59) | CYP3A4TP53CHRM2CHRM1CHRM3 | |
| Ammonia Solution, Strong SCHEMBL27668328 | 0.82 | TP53 (0.57) | CYP3A4TP53CHRM2CHRM1CHRM3 | |
| SCHEMBL6181647 | 0.81 | CHRM2 (0.59) | CYP3A4TP53CHRM2CHRM1CHRM3 | |
| 1,3-Diethoxybenzene SCHEMBL1100167 | 0.80 | TP53 (0.71) | CYP3A4TP53SMN1; SMN2NQO1LTA4H | |
| SCHEMBL606214 | 0.80 | TP53 (0.60) | CYP3A4TP53CHRM2CHRM1CHRM3 | |
| SCHEMBL427612 | 0.80 | CHRM2 (0.58) | CYP3A4TP53CHRM2CHRM1CHRM3 | |
| SCHEMBL2937407 | 0.80 | TP53 (0.55) | CYP3A4TP53CHRM2CHRM1CHRM3 | |
| SCHEMBL4353971 | 0.80 | CHRM2 (0.58) | CYP3A4TP53CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496578-A2 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME | University of Notre Dame du Lac (US) | 2012-09-12 | — | — | EP | claimed |
| US-20120220457-A1 | IMIDAZO [1,2-a]PYRIDINE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME | DOW AGROSCIENCES LLC (US) | 2012-08-30 | — | — | US | claimed |
| WO-2011057145-A2 | IMIDAZO[1,2-A] PYRIDINE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2011-05-12 | — | — | WO | claimed |
| US-10913737-B2 | Imidazo [1,2-a]pyridine compounds, synthesis thereof, and methods of using same | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2021-02-09 | — | — | US | disclosed |
| US-20180354944-A1 | IMIDAZO [1,2-a]PYRIDINE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2018-12-13 | — | — | US | disclosed |
| US-9908876-B2 | Imidazo [1,2-a]pyridine compounds, synthesis thereof, and methods of using same | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2018-03-06 | — | — | US | disclosed |
| EP-3257854-A1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME | University of Notre Dame du Lac (US) | 2017-12-20 | — | — | EP | disclosed |
| US-20160318925-A1 | IMIDAZO [1,2-a]PYRIDINE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2016-11-03 | — | — | US | disclosed |
| US-9309238-B2 | Imidazo [1,2-a]pyridine compounds, synthesis thereof, and methods of using same | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2016-04-12 | — | — | US | disclosed |
| EP-2496578-A2 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME | University of Notre Dame du Lac (US) | 2012-09-12 | — | — | EP | disclosed |
| US-20120220457-A1 | IMIDAZO [1,2-a]PYRIDINE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME | DOW AGROSCIENCES LLC (US) | 2012-08-30 | — | — | US | disclosed |
| WO-2011057145-A2 | IMIDAZO[1,2-A] PYRIDINE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2011-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10913737-B2 | Imidazo [1,2-a]pyridine compounds, synthesis thereof, and methods of using same | RIF1, PYCR1, PNMT | CYP3A4 1841/4885TP53 1737/4885CHRM2 2430/4885 |
| US-20160318925-A1 | IMIDAZO [1,2-a]PYRIDINE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME | RIF1, PYCR1, PNMT | CYP3A4 1841/4885TP53 1737/4885CHRM2 2430/4885 |
| US-20120220457-A1 | IMIDAZO [1,2-a]PYRIDINE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME | RIF1, PYCR1, PNMT | CYP3A4 1841/4885TP53 1737/4885CHRM2 2430/4885 |
| US-20180354944-A1 | IMIDAZO [1,2-a]PYRIDINE COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME | RIF1, PYCR1, PNMT | CYP3A4 1841/4885TP53 1737/4885CHRM2 2430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.