Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL304176 | 0.75 | TDP1 (0.78) | KMT2AALDH1A1MAPK1L3MBTL1TDP1 | |
| SCHEMBL3708328 | 0.74 | TDP1 (0.66) | MEN1KMT2AALDH1A1MAPK1L3MBTL1 | |
| Ammonia Solution, Strong SCHEMBL28588274 | 0.73 | TDP1 (0.75) | KMT2AALDH1A1MAPK1L3MBTL1TDP1 | |
| SCHEMBL28207503 | 0.73 | TDP1 (0.75) | KMT2AALDH1A1MAPK1L3MBTL1TDP1 | |
| Bicarbonate SCHEMBL7699565 | 0.73 | TDP1 (0.75) | KMT2AALDH1A1MAPK1L3MBTL1TDP1 | |
| SCHEMBL28450115 | 0.73 | TDP1 (0.64) | MEN1KMT2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL28662041 | 0.73 | TDP1 (0.54) | KMT2AALDH1A1MAPK1L3MBTL1TDP1 | |
| SCHEMBL1177836 | 0.73 | ALDH1A1 (0.73) | MEN1KMT2AALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL8553345 | 0.72 | ALDH1A1 (0.50) | MEN1KMT2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL16366524 | 0.72 | ALDH1A1 (0.46) | MEN1KMT2AKDM4ECYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011061271-A1 | SUBSTITUTED CARBAMOYLMETHYLAMINO ACETIC ACID DERIVATIVES AS NOVEL NEP INHIBITORS | NOVARTIS AG (CH) | 2011-05-26 | — | — | WO | disclosed |