Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17685319 | 1.00 | ALDH1A1 (0.32) | ALDH1A1LMNAKDM4EHPGDMAPK1 | |
| SCHEMBL17685327 | 0.80 | JAK2 (0.39) | JAK1JAK2 | |
| SCHEMBL17685326 | 0.80 | JAK2 (0.39) | JAK1JAK2 | |
| SCHEMBL13504387 | 0.77 | JAK2 (0.36) | JAK1JAK2 | |
| SCHEMBL13504391 | 0.77 | JAK2 (0.36) | JAK1JAK2 | |
| SCHEMBL377034 | 0.71 | ALDH1A1 (0.34) | ALDH1A1HCRTR2HCRTR1 | |
| SCHEMBL17685329 | 0.70 | JAK2 (0.40) | JAK1JAK2 | |
| SCHEMBL17685328 | 0.70 | JAK2 (0.40) | JAK1JAK2 | |
| SCHEMBL17027774 | 0.69 | L3MBTL1 (0.40) | ALDH1A1LMNAKDM4EHTTL3MBTL1 | |
| SCHEMBL29711712 | 0.69 | L3MBTL1 (0.40) | ALDH1A1LMNAKDM4EHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-B1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2016-04-20 | — | — | EP | disclosed |