Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.42 |
| ▸ | RAB9A | P51151 | 9/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15361552 | 0.78 | TDP1 (0.51) | NPC1RAB9ATSHRDDAH1PKM | |
| SCHEMBL1918882 | 0.76 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL3719874 | 0.74 | MAPT (0.36) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL693173 | 0.73 | GAA (0.66) | NPC1RAB9ASMN1; SMN2TSHRPKM | |
| SCHEMBL694076 | 0.72 | RAB9A (0.67) | NPC1RAB9ASMN1; SMN2ALDH1A1PKM | |
| SCHEMBL2077576 | 0.72 | ALDH1A1 (0.47) | NPC1RAB9ASMN1; SMN2ALDH1A1PKM | |
| SCHEMBL1661454 | 0.71 | CHRM1 (0.64) | ALDH1A1PKMGAAKDM4EMAPT | |
| SCHEMBL5840408 | 0.70 | CACNA1H (0.40) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL16097952 | 0.69 | — | — | |
| SCHEMBL16719715 | 0.69 | MAPT (0.37) | ALDH1A1GAAMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-B1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2016-04-20 | — | — | EP | claimed |