Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | EBP | Q15125 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17685375 | 1.00 | CCR5 (0.43) | CCR5KDM4EATMNPSR1TDP1 | |
| SCHEMBL383264 | 0.93 | CCR5 (0.47) | CCR5KDM4EATMNPSR1TDP1 | |
| SCHEMBL383265 | 0.93 | CCR5 (0.47) | CCR5KDM4EATMNPSR1TDP1 | |
| SCHEMBL2144199 | 0.93 | CCR5 (0.47) | CCR5KDM4EATMNPSR1TDP1 | |
| Hydrochloric Acid SCHEMBL28453731 | 0.87 | YTHDC1 (0.43) | CCR5KDM4EATMNPSR1TDP1 | |
| SCHEMBL372240 | 0.83 | YTHDC1 (0.51) | KDM4EATMNPSR1TDP1YTHDC1 | |
| SCHEMBL372241 | 0.83 | YTHDC1 (0.51) | KDM4EATMNPSR1TDP1YTHDC1 | |
| Hydrochloric Acid SCHEMBL30335838 | 0.81 | YTHDC1 (0.50) | KDM4EATMNPSR1TDP1YTHDC1 | |
| SCHEMBL24678312 | 0.80 | KDM4E (0.47) | CCR5KDM4EATMNPSR1TDP1 | |
| SCHEMBL17685339 | 0.79 | YTHDC1 (0.49) | CCR5YTHDC1SLC6A2SLC6A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-B1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2016-04-20 | — | — | EP | disclosed |