Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Carbinoxamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 6/20 | 0.84 |
| ▸ | CHRM2 | P08172 | 8/20 | 0.84 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.84 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.84 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.84 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.84 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.84 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.84 |
| ▸ | LMNA | P02545 | 5/20 | 0.84 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.84 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.84 |
| ▸ | POLB | P06746 | 1/20 | 0.74 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.54 |
| ▸ | HTR2A | P28223 | 4/20 | 0.54 |
| ▸ | SCN1A | P35498 | 4/20 | 0.54 |
| ▸ | SCN2A | Q99250 | 4/20 | 0.54 |
| ▸ | SCN3A | Q9NY46 | 4/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.54 |
| ▸ | HRH2 | P25021 | 3/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rotoxamine SCHEMBL29485023 | 0.92 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4SLC6A3HRH1 | |
| Carbinoxamine SCHEMBL29414093 | 0.92 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4SLC6A3HRH1 | |
| Rotoxamine SCHEMBL141389 | 0.92 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4SLC6A3HRH1 | |
| Carbinoxamine SCHEMBL5070 | 0.92 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4SLC6A3HRH1 | |
| Carbinoxamine SCHEMBL29881788 | 0.92 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4SLC6A3HRH1 | |
| Carbinoxamine SCHEMBL8709373 | 0.91 | CHRM2 (0.97) | CHRM2SLC6A2SLC6A4SLC6A3HRH1 | |
| Carbinoxamine SCHEMBL662375 | 0.89 | CHRM2 (0.93) | CHRM2SLC6A2SLC6A4SLC6A3HRH1 | |
| Carbinoxamine SCHEMBL9095143 | 0.87 | CHRM2 (0.91) | CHRM2SLC6A2SLC6A4SLC6A3HRH1 | |
| Carbinoxamine SCHEMBL6626762 | 0.87 | CHRM2 (0.91) | CHRM2SLC6A2SLC6A4SLC6A3HRH1 | |
| Rotoxamine SCHEMBL6312191 | 0.86 | CHRM2 (0.83) | CHRM2SLC6A2SLC6A4SLC6A3HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114040767-A | Methods and compositions comprising 5HT receptor agonists for the treatment of psychological, cognitive, behavioral and/or emotional disorders | 钻石治疗公司 | 2022-02-11 | — | — | CN | disclosed |
| US-9775837-B2 | Pharmaceutical compositions | CHARLESTON LABORATORIES, INC. (US) | 2017-10-03 | — | — | US | disclosed |
| US-20160106755-A1 | PHARMACEUTICAL COMPOSITIONS | CHARLESTON LABORATORIES, INC. | 2016-04-21 | — | — | US | disclosed |