Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Carbinoxamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.97 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.97 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.97 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.97 |
| ▸ | LMNA | P02545 | 6/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.97 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.97 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.97 |
| ▸ | POLB | P06746 | 1/20 | 0.79 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.61 |
| ▸ | SCN1A | P35498 | 4/20 | 0.61 |
| ▸ | SCN2A | Q99250 | 4/20 | 0.61 |
| ▸ | SCN3A | Q9NY46 | 4/20 | 0.61 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.61 |
| ▸ | HRH2 | P25021 | 3/20 | 0.61 |
| ▸ | HTR2A | P28223 | 3/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbinoxamine SCHEMBL29881788 | 0.99 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4SLC6A3LMNA | |
| Rotoxamine SCHEMBL141389 | 0.99 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4SLC6A3LMNA | |
| Carbinoxamine SCHEMBL29414093 | 0.99 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4SLC6A3LMNA | |
| Rotoxamine SCHEMBL29485023 | 0.99 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4SLC6A3LMNA | |
| Carbinoxamine SCHEMBL5070 | 0.99 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4SLC6A3LMNA | |
| Carbinoxamine SCHEMBL9095143 | 0.96 | CHRM2 (0.91) | CHRM2SLC6A2SLC6A4SLC6A3LMNA | |
| Carbinoxamine SCHEMBL662375 | 0.95 | CHRM2 (0.93) | CHRM2SLC6A2SLC6A4SLC6A3LMNA | |
| Carbinoxamine SCHEMBL6626762 | 0.94 | CHRM2 (0.91) | CHRM2SLC6A2SLC6A4SLC6A3LMNA | |
| Carbinoxamine SCHEMBL17685697 | 0.91 | CHRM2 (0.84) | CHRM2SLC6A2SLC6A4SLC6A3LMNA | |
| Carbinoxamine SCHEMBL4074917 | 0.90 | CHRM2 (0.83) | CHRM2SLC6A2SLC6A4SLC6A3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608322-B1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON VICKS INC (US) | 1998-07-22 | — | — | EP | claimed |
| US-5756118-A | CONSISTS OF AQUEOUS CARRIER, AN ANTIHISTAMINE DRUG AND NONIONIC POLYACRYLAMIDE BEING PREDISPERSED IN WATER-IMMISCIBLE OIL CONTAINING SURFACTANT HAVING HYDROPHILIC-LIPOPHILIC BALANCE ABOUT 7 TO 10 | RICHARDSON-VICKS INC. (US) | 1998-05-26 | — | — | US | claimed |
| EP-0608320-B1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON VICKS INC (US) | 1998-01-28 | — | — | EP | claimed |
| EP-0652774-B1 | PHARMACEUTICAL COMPOSITION FOR TOPICAL USE CONTAINING A CROSSLINKED CATIONIC POLYMER AND AN ALKOXYLATED ETHER | PROCTER & GAMBLE (US) | 1997-05-07 | — | — | EP | claimed |
| US-5614178-A | TRANSDERMAL | THE PROCTER & GAMBLE COMPANY (US) | 1997-03-25 | — | — | US | claimed |
| EP-0652774-A1 | PHARMACEUTICAL COMPOSITION FOR TOPICAL USE CONTAINING A CROSSLINKED CATIONIC POLYMER AND AN ALKOXYLATED ETHER. | PROCTER & GAMBLE (US) | 1995-05-17 | — | — | EP | claimed |
| EP-0608320-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1994-08-03 | — | — | EP | claimed |
| EP-0608322-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1994-08-03 | — | — | EP | claimed |
| WO-1994002176-A1 | PHARMACEUTICAL COMPOSITION FOR TOPICAL USE CONTAINING A CROSSLINKED CATIONIC POLYMER AND AN ALKOXYLATED ETHER | THE PROCTER & GAMBLE COMPANY (US) | 1994-02-03 | — | — | WO | claimed |
| WO-1993007902-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1993-04-29 | — | — | WO | claimed |
| WO-1993007903-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1993-04-29 | — | — | WO | claimed |
| EP-0351897-A2 | Skin penetration system for salts of amine-functional drugs | THE PROCTER & GAMBLE COMPANY (US) | 1990-01-24 | — | — | EP | disclosed |