Trifluoromethylbenzene

Trifluoromethylbenzene

SCHEMBL1768875

CNC.FC(F)(F)c1ccccc1

nearest known ligand 0.78

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.78
ALDH1A1 P00352 2/20 0.78
KIF11 P52732 2/20 0.56
KCNN4 O15554 1/20 0.52
TRPV6 Q9H1D0 1/20 0.46
RAB9A P51151 4/20 0.45
NPC1 O15118 3/20 0.45
OPRM1 P35372 3/20 0.44
OPRL1 P41146 2/20 0.44
CYP19A1 P11511 1/20 0.44
MEN1 O00255 5/20 0.42
KMT2A Q03164 5/20 0.42
HTT P42858 2/20 0.42
IDH2 P48735 2/20 0.42
MAPT P10636 1/20 0.42
LMNA P02545 4/20 0.42
SLC6A2 P23975 3/20 0.42
SLC6A4 P31645 3/20 0.42
SLC6A3 Q01959 3/20 0.42
CYP2D6 P10635 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoromethylbenzene SCHEMBL21879063 0.88 TSHR (0.88) TSHRALDH1A1KIF11KCNN4TRPV6
Trifluoromethylbenzene SCHEMBL4867878 0.88 TSHR (0.88) TSHRALDH1A1KIF11KCNN4TRPV6
Trifluoromethylbenzene SCHEMBL27760126 0.88 TSHR (1.00) TSHRALDH1A1KIF11KCNN4TRPV6
Trifluoromethylbenzene SCHEMBL8692 0.88 TSHR (1.00) TSHRALDH1A1KIF11KCNN4TRPV6
Trifluoromethylbenzene SCHEMBL175647 0.88 TSHR (1.00) TSHRALDH1A1KIF11KCNN4TRPV6
Trifluoromethylbenzene SCHEMBL5311703 0.86 ALDH1A1 (0.82) TSHRALDH1A1KIF11TRPV6RAB9A
Trifluoromethylbenzene SCHEMBL11580827 0.86 TSHR (0.82) TSHRALDH1A1KIF11KCNN4TRPV6
Trifluoromethylbenzene SCHEMBL18787459 0.86 TSHR (0.82) TSHRALDH1A1KIF11KCNN4TRPV6
Trifluoromethylbenzene SCHEMBL9482280 0.85 TSHR (0.93) TSHRALDH1A1KIF11KCNN4TRPV6
Trifluoromethylbenzene SCHEMBL22806921 0.85 TSHR (0.93) TSHRALDH1A1KIF11KCNN4TRPV6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011058576-A1 PROCESS FOR PREPARING POLYHALOGENATED PERHALOALKYLANILINE GHARDA KEKI HORMUSJI (IN) 2011-05-19 WO disclosed
WO-2011058577-A1 PROCESS FOR SYNTHESIZING POLYHALOGENATED PERHALOALKYLANILINE COMPOUNDS GHARDA KEKI HORMUSJI (IN) 2011-05-19 WO disclosed
EP-0491326-A2 Process for the functionalization of trifluoromethylbenzenes ISTITUTO GUIDO DONEGANI S.p.A. (IT) 1992-06-24 EP disclosed
US-4096185-A P-CHLOROBENZOTRIFLUORIDE, AMMONIA, COPPER COMPOUND CATALYST E. I. DU PONT DE NEMOURS AND COMPANY (US) 1978-06-20 US disclosed
US-4006127-A Cationic diazacyanine dyestuffs BAYER AKTIENGESELLSCHAFT (DT) 1977-02-01 US disclosed