Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 2/20 | 0.42 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17207206 | 0.80 | SMN1; SMN2 (0.57) | KCNH2SMN1; SMN2TSHRMAPTKMT2A | |
| SCHEMBL20319007 | 0.69 | HTT (0.42) | SMN1; SMN2TSHRMAPTLMNAHTT | |
| SCHEMBL4747138 | 0.68 | CHRM2 (0.63) | KCNH2SMN1; SMN2TSHRMAPTKMT2A | |
| SCHEMBL11567282 | 0.68 | GAA (0.49) | SMN1; SMN2TSHRMAPTKMT2ALMNA | |
| SCHEMBL17688927 | 0.68 | CYP1A2 (0.56) | PTGS2SMN1; SMN2TSHRMAPTKMT2A | |
| SCHEMBL17342208 | 0.68 | — | — | |
| SCHEMBL22941521 | 0.67 | RAB9A (0.43) | SMN1; SMN2TSHRMAPTKMT2ALMNA | |
| SCHEMBL4852129 | 0.66 | KDM4C (0.47) | SMN1; SMN2TSHRMAPTKMT2AALDH1A1 | |
| SCHEMBL2954326 | 0.66 | HCRTR1 (0.55) | LMNAALDH1A1KDM4E | |
| SCHEMBL12889093 | 0.65 | ALDH1A1 (0.54) | KCNH2SMN1; SMN2TSHRMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9315494-B2 | Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFNα responses | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-04-19 | — | — | US | disclosed |