Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17092727 | 0.84 | NAMPT (0.47) | NAMPTKDM4EMAPTTHRBPDE4B | |
| SCHEMBL23411339 | 0.81 | KDM4E (0.52) | NAMPTKDM4EMAPTTHRBPDE4B | |
| SCHEMBL29891481 | 0.80 | NAMPT (0.49) | NAMPTKDM4EMAPTTHRBPDE4B | |
| SCHEMBL23411311 | 0.80 | NAMPT (0.49) | NAMPTKDM4EMAPTTHRBPDE4B | |
| SCHEMBL17109202 | 0.80 | TP53 (0.46) | NAMPTKDM4EMAPTTHRBPDE4B | |
| SCHEMBL23211951 | 0.78 | GPR119 (0.51) | NAMPTKDM4EMAPTTHRBPDE4B | |
| SCHEMBL30149799 | 0.78 | GPR119 (0.51) | NAMPTKDM4EMAPTTHRBPDE4B | |
| SCHEMBL14635623 | 0.77 | NAMPT (0.58) | NAMPTKDM4EMAPTTHRBPDE4B | |
| SCHEMBL16965440 | 0.77 | NAMPT (0.58) | NAMPTKDM4EMAPTTHRBPDE4B | |
| SCHEMBL2636994 | 0.77 | HSD11B1 (0.68) | NAMPTKDM4EMAPTTHRBPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3009424-B1 | BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND | ASTELLAS PHARMA INC (JP) | 2017-12-20 | — | — | EP | disclosed |
| EP-3009424-A1 | BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2016-04-20 | — | — | EP | disclosed |