SCHEMBL1769241

SCHEMBL1769241

O=C1Nc2ncccc2CC12CCNCC2

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CALCA P06881 1/20 0.36
OTUD7B Q6GQQ9 2/20 0.36
CRBN Q96SW2 2/20 0.36
NPC1 O15118 1/20 0.35
MAPK1 P28482 2/20 0.35
NPSR1 Q6W5P4 1/20 0.35
HSD17B10 Q99714 4/20 0.34
ALDH1A1 P00352 3/20 0.34
HPGD P15428 3/20 0.34
CYP1A2 P05177 2/20 0.34
CYP3A4 P08684 2/20 0.33
CYP2D6 P10635 2/20 0.33
TSHR P16473 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
MEN1 O00255 1/20 0.33
USP2 O75604 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
KMT2A Q03164 1/20 0.33
IDH1 O75874 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15690225 0.91 OTUD7B (0.39) OTUD7BCRBNNPC1MAPK1NPSR1
Trifluoroacetic Acid SCHEMBL14995239 0.89 L3MBTL1 (0.37) CALCANPC1IDH1
Trifluoroacetic Acid SCHEMBL30365543 0.89 L3MBTL1 (0.37) CALCANPC1IDH1
SCHEMBL15690307 0.88 MAPK1 (0.42) OTUD7BCRBNNPC1MAPK1NPSR1
SCHEMBL15690420 0.86 MAPK1 (0.44) OTUD7BCRBNNPC1MAPK1NPSR1
SCHEMBL15690568 0.86 CRBN (0.39) OTUD7BCRBNNPC1MAPK1NPSR1
SCHEMBL15690450 0.84 OTUD7B (0.38) CALCAOTUD7BCRBNNPC1MAPK1
SCHEMBL25707439 0.77 MAPK1 (0.35) MAPK1NPSR1HSD17B10ALDH1A1HPGD
Hydrochloric Acid SCHEMBL25232629 0.76 MAPK1 (0.35) MAPK1NPSR1HSD17B10ALDH1A1HPGD
Hydrochloric Acid SCHEMBL30486598 0.76 MAPK1 (0.35) MAPK1NPSR1HSD17B10ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2785715-A1 SUBSTITUTED PYRIDINE DERIVATIVES AS FABI INHIBITORS Aurigene Discovery Technologies Limited (IN) 2014-10-08 EP claimed
WO-2013080222-A1 SUBSTITUTED PYRIDINE DERIVATIVES AS FABI INHIBITORS AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) 2013-06-06 WO claimed
EP-2501693-A1 NOVEL HETEROCYCLIC ACRYLAMIDES AND THEIR USE AS PHARMACEUTICALS FAB Pharma SAS (FR) 2012-09-26 EP claimed
WO-2011061214-A1 NOVEL HETEROCYCLIC ACRYLAMIDES AND THEIR USE AS PHARMACEUTICALS FAB PHARMA SAS (FR) 2011-05-26 WO claimed
EP-2785693-A1 ARYL DIHYDROPYRIDINONES AND PIPERIDINONES AS MGAT2 INHIBITORS Bristol-Myers Squibb Company (US) 2014-10-08 EP disclosed
WO-2013082345-A9 ARYL DIHYDROPYRIDINONES AND PIPERIDINONES AS MGAT2 INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2014-09-25 WO disclosed
WO-2014072930-A2 FUSED PYRIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) 2014-05-15 WO disclosed
WO-2013082345-A1 ARYL DIHYDROPYRIDINONE AND PIPERIDINONE AS MGAT2 INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2013-06-06 WO disclosed
EP-2501693-A1 NOVEL HETEROCYCLIC ACRYLAMIDES AND THEIR USE AS PHARMACEUTICALS FAB Pharma SAS (FR) 2012-09-26 EP disclosed
WO-2011061214-A1 NOVEL HETEROCYCLIC ACRYLAMIDES AND THEIR USE AS PHARMACEUTICALS FAB PHARMA SAS (FR) 2011-05-26 WO disclosed