SCHEMBL1769277

SCHEMBL1769277

NCc1ccc(OCCC2CC3CC3N2)cn1

nearest known ligand 0.69

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 20/20 0.69
CHRNA4 P43681 20/20 0.69
CYP2D6 P10635 6/20 0.51
CHRNB4 P30926 4/20 0.51
CHRNA3 P32297 4/20 0.51
CYP3A4 P08684 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1769429 0.84 CHRNB2 (0.72) CHRNB2CHRNA4CYP2D6CHRNB4CHRNA3
SCHEMBL14776793 0.77 CHRNB2 (0.66) CHRNB2CHRNA4CYP2D6CHRNB4CHRNA3
SCHEMBL1769449 0.74 CHRNB2 (0.69) CHRNB2CHRNA4CYP2D6CHRNB4CHRNA3
SCHEMBL1769276 0.72 CHRNB2 (0.43) CHRNB2CHRNA4CYP2D6CHRNB4CHRNA3
SCHEMBL14776792 0.72 CHRNB2 (0.67) CHRNB2CHRNA4CYP2D6CHRNB4CHRNA3
SCHEMBL14776262 0.72 CHRNB2 (0.67) CHRNB2CHRNA4CYP2D6CHRNB4CHRNA3
SCHEMBL18092157 0.70 CHRNB2 (0.97) CHRNB2CHRNA4CYP2D6CHRNB4CHRNA3
SCHEMBL22604312 0.69 NCF1 (0.41)
Ropanicant SCHEMBL18092155 0.69 CHRNB2 (0.97) CHRNB2CHRNA4CYP2D6CHRNB4CHRNA3
Hydrochloric Acid SCHEMBL1769403 0.69 CHRNB2 (1.00) CHRNB2CHRNA4CYP2D6CHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2513085-A1 BICYCLIC COMPOUNDS AS alpha4beta2 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS Suven Life Sciences Limited (IN) 2012-10-24 EP claimed
WO-2011061751-A1 BICYCLIC COMPOUNDS AS α4β2 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS SUVEN LIFE SCIENCES LIMITED (IN) 2011-05-26 WO claimed
EP-2513085-A1 BICYCLIC COMPOUNDS AS alpha4beta2 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS Suven Life Sciences Limited (IN) 2012-10-24 EP disclosed
WO-2011061751-A1 BICYCLIC COMPOUNDS AS α4β2 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS SUVEN LIFE SCIENCES LIMITED (IN) 2011-05-26 WO disclosed