Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | KLKB1 | P03952 | 8/20 | 0.48 |
| ▸ | KLK1 | P06870 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ESRRG | P62508 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4188538 | 0.87 | HSD17B10 (0.61) | ALDH1A1KDM4EHSD17B10KLKB1KLK1 | |
| SCHEMBL31591079 | 0.86 | KLKB1 (0.44) | ALDH1A1KDM4EHSD17B10KLKB1KLK1 | |
| SCHEMBL17696410 | 0.84 | KLKB1 (0.55) | ALDH1A1KDM4EHSD17B10KLKB1KLK1 | |
| SCHEMBL31591076 | 0.82 | KLKB1 (0.51) | ALDH1A1KDM4EHSD17B10KLKB1KLK1 | |
| SCHEMBL15964732 | 0.81 | KLKB1 (0.60) | ALDH1A1KDM4EHSD17B10KLKB1LMNA | |
| SCHEMBL2272882 | 0.81 | L3MBTL1 (0.57) | ALDH1A1KDM4EHSD17B10KLKB1MEN1 | |
| SCHEMBL31591087 | 0.81 | KLKB1 (0.46) | ALDH1A1KDM4EHSD17B10KLKB1KLK1 | |
| SCHEMBL31591091 | 0.78 | KLKB1 (0.48) | ALDH1A1KDM4EHSD17B10KLKB1KLK1 | |
| SCHEMBL31591063 | 0.78 | KLKB1 (0.47) | ALDH1A1KDM4EHSD17B10KLKB1KLK1 | |
| SCHEMBL31591069 | 0.78 | KLKB1 (0.45) | ALDH1A1KDM4EHSD17B10KLKB1KLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9533987-B2 | Heterocyclic derivates | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2017-01-03 | — | — | US | disclosed |
| US-20160108036-A1 | HETEROCYCLIC DERIVATES | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160108036-A1 | HETEROCYCLIC DERIVATES | BDKRB1, KLKB1, BDKRB2 | ALDH1A1 1517/4885KDM4E 1167/4885HSD17B10 1354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.