Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 13/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 13/20 | 0.54 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.35 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.35 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1769227 | 0.82 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL1769195 | 0.81 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL14776776 | 0.70 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL14776666 | 0.70 | CHRNB2 (0.97) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL14776261 | 0.69 | CHRNB2 (0.97) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL1769296 | 0.69 | CHRNB2 (0.69) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL14776556 | 0.68 | CHRNB2 (0.72) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL1769412 | 0.68 | CHRNB2 (0.70) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL14776559 | 0.68 | CHRNB2 (0.70) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 | |
| SCHEMBL14776264 | 0.67 | CHRNB2 (0.69) | CHRNB2CHRNA4CHRNA3CHRNB1CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513085-A1 | BICYCLIC COMPOUNDS AS alpha4beta2 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | Suven Life Sciences Limited (IN) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011061751-A1 | BICYCLIC COMPOUNDS AS α4β2 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2011-05-26 | — | — | WO | disclosed |