Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20078937 | 0.84 | LMNA (0.33) | LMNAKDM4ERAB9AALDH1A1NPC1 | |
| SCHEMBL24878752 | 0.72 | ALDH1A1 (0.35) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL19890884 | 0.71 | MAPK1 (0.36) | KDM4EALDH1A1KMT2ASMN1; SMN2MAPK1 | |
| SCHEMBL16006682 | 0.70 | PDE4A (0.33) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL21995999 | 0.70 | PDE4A (0.33) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL17695171 | 0.70 | PDE4A (0.33) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL16145220 | 0.69 | — | — | |
| SCHEMBL17695172 | 0.69 | KDM4E (0.32) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL24878758 | 0.69 | KDM4E (0.32) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL16006579 | 0.69 | KDM4E (0.32) | PDE4APDE4BPDE4CPDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160108030-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. | 2016-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160108030-A1 | THERAPEUTIC COMPOUNDS | HAVCR2, SARS1, RPL35 | PDE4A 3273/4885PDE4B 2755/4885PDE4C 3045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.