Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Glycerin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 5/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycerin SCHEMBL8846308 | 0.94 | TDP1 (0.62) | LMNAALDH1A1TDP1TSHRTHRB | |
| Glycerin SCHEMBL5249319 | 0.93 | LMNA (0.75) | LMNAALDH1A1TDP1TSHRTHRB | |
| Glycerin SCHEMBL29231 | 0.93 | — | — | |
| Glycerin SCHEMBL7455556 | 0.93 | LMNA (0.75) | LMNAALDH1A1TDP1TSHRTHRB | |
| Glycerin SCHEMBL8773344 | 0.93 | LMNA (0.75) | LMNAALDH1A1TDP1TSHRTHRB | |
| Glycerin SCHEMBL2553942 | 0.93 | LMNA (0.75) | LMNAALDH1A1TDP1TSHRTHRB | |
| Glycerin SCHEMBL8328338 | 0.93 | LMNA (0.75) | LMNAALDH1A1TDP1TSHRTHRB | |
| Glycerin SCHEMBL1081867 | 0.93 | LMNA (0.75) | LMNAALDH1A1TDP1TSHRTHRB | |
| Glycerin SCHEMBL8592118 | 0.90 | TDP1 (0.67) | LMNAALDH1A1TDP1TSHRTHRB | |
| Glycerin SCHEMBL23630291 | 0.89 | LMNA (0.69) | LMNAALDH1A1TDP1TSHRTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109337766-A | High and cold freeze proof bath of glass and preparation method | 哈尔滨学院 | 2019-02-15 | — | — | CN | disclosed |
| EP-2793962-B1 | PROCESS FOR MODIFYING THE SURFACE MORPHOLOGY OF A MEDICAL DEVICE | LE DANG QUANG SVEND (DK) | 2016-04-27 | — | — | EP | disclosed |