Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 1/20 | 0.35 |
| ▸ | EDNRA | P25101 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5078519 | 0.83 | EDNRB (0.35) | EDNRBEDNRAMAPTNPC1LMNA | |
| Hydrochloric Acid SCHEMBL3685212 | 0.82 | ALDH1A1 (0.33) | MAPTNPC1ALDH1A1RAB9AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL2866626 | 0.74 | BCL2 (0.35) | EDNRBEDNRAMAPTNPC1ALDH1A1 | |
| SCHEMBL22797325 | 0.72 | BCL2 (0.42) | EDNRBEDNRAMAPTNPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5352100 | 0.72 | ALDH1A1 (0.46) | EDNRBEDNRAMAPTNPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL17698590 | 0.71 | NPC1 (0.31) | MAPTNPC1ALDH1A1LMNAMAPK1 | |
| SCHEMBL2866629 | 0.70 | BCL2 (0.33) | EDNRBEDNRABCL2 | |
| Hydrochloric Acid SCHEMBL7272244 | 0.68 | ELANE (0.36) | EDNRBEDNRAMAPTNPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2861106 | 0.68 | BCL2 (0.38) | EDNRBEDNRAMAPTNPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2479388 | 0.66 | CYP1A2 (0.38) | EDNRBEDNRAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1473323-B1 | Polyethylene composition and process for producing same | TOSOH CORP (JP) | 2016-04-27 | — | — | EP | disclosed |