Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.38 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.35 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.35 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17289037 | 0.84 | HRH1 (0.44) | IKZF2L3MBTL1HRH1KDM4ECYP1A2 | |
| SCHEMBL20007069 | 0.80 | IKZF2 (0.39) | IKZF2L3MBTL1HRH1KDM4ESMN1; SMN2 | |
| SCHEMBL18652040 | 0.80 | HRH1 (0.40) | IKZF2HRH1KDM4ECYP1A2CYP2C19 | |
| SCHEMBL5962222 | 0.80 | HRH3 (0.45) | L3MBTL1HRH1KDM4EHRH3CYP1A2 | |
| SCHEMBL803399 | 0.79 | KDM4E (0.40) | IKZF2L3MBTL1HRH1KDM4ESMN1; SMN2 | |
| SCHEMBL2495181 | 0.79 | L3MBTL1 (0.62) | L3MBTL1KDM4ESMN1; SMN2OPRM1CYP1A2 | |
| Hydrochloric Acid SCHEMBL1392032 | 0.77 | L3MBTL1 (0.65) | L3MBTL1KDM4ESMN1; SMN2OPRM1CYP1A2 | |
| SCHEMBL14980280 | 0.77 | KDM4E (0.46) | HRH1KDM4ECYP1A2CYP2C19KMT2A | |
| SCHEMBL9933634 | 0.77 | CXCR4 (0.49) | L3MBTL1HRH1HRH3KMT2A | |
| SCHEMBL1586376 | 0.76 | SIGMAR1 (0.50) | KDM4EKMT2ATRPV6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9579319-B2 | Heterocyclic compounds as hedgehog signaling pathway inhibitors | REDX PHARMA PLC (GB) | 2017-02-28 | — | — | US | disclosed |
| US-20160113928-A1 | HETEROCYCLIC COMPOUNDS AS HEDGEHOG SIGNALING PATHWAY INHIBITORS | REDX PHARMA PLC (GB) | 2016-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160113928-A1 | HETEROCYCLIC COMPOUNDS AS HEDGEHOG SIGNALING PATHWAY INHIBITORS | SMO, SHH, GLI1 | IKZF2 167/4885L3MBTL1 3762/4885HRH1 159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.