Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 9/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1769973 | 0.98 | HDAC4 (0.57) | HDAC4HSD11B1ALDH1A1CHRM2CHRM1 | |
| SCHEMBL1769960 | 0.97 | HDAC4 (0.54) | HDAC4HSD11B1ALDH1A1CHRM2CHRM1 | |
| SCHEMBL1769917 | 0.93 | HSD11B1 (0.51) | HDAC4HSD11B1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5845670 | 0.84 | HDAC4 (0.60) | HDAC4HSD11B1ALDH1A1CHRM2CHRM1 | |
| SCHEMBL6499510 | 0.83 | HDAC4 (0.58) | HDAC4HSD11B1ALDH1A1CHRM2CHRM1 | |
| SCHEMBL5844319 | 0.83 | HDAC4 (0.58) | HDAC4HSD11B1ALDH1A1CHRM2CHRM1 | |
| SCHEMBL7366120 | 0.82 | CHRM2 (0.49) | CHRM2CHRM1 | |
| SCHEMBL13267655 | 0.81 | HDAC4 (0.57) | HDAC4HSD11B1ALDH1A1CHRM2CHRM1 | |
| SCHEMBL3443916 | 0.81 | HDAC4 (0.56) | HDAC4HSD11B1ALDH1A1HDAC1SMN1; SMN2 | |
| SCHEMBL1770373 | 0.81 | HDAC4 (0.56) | HDAC4HSD11B1ALDH1A1HDAC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112151-A1 | COMPOUND CAPABLE OF INHIBITING 11-BETA HYDROXYSTERIOD DEHYDROGENASE | STERIX LIMITED (GB) | 2011-05-12 | — | — | US | disclosed |
| EP-2257528-A2 | 1 IBETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Sterix Limited (GB) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009106817-A2 | COMPOUND | STERIX LIMITED (GB) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112151-A1 | COMPOUND CAPABLE OF INHIBITING 11-BETA HYDROXYSTERIOD DEHYDROGENASE | HSD11B1, HSD11B2, HSD3B1 | HDAC4 1338/4885HSD11B1 1/4885ALDH1A1 307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.