Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 14/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.45 |
| ▸ | EED | O75530 | 1/20 | 0.39 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.39 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.39 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 3/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16052395 | 0.82 | CDK9 (0.55) | CDK9CCNT1 | |
| SCHEMBL17535146 | 0.81 | CDK9 (0.47) | CDK9CCNT1 | |
| SCHEMBL16967654 | 0.75 | CDK9 (0.39) | CDK9 | |
| SCHEMBL16039104 | 0.75 | CDK9 (0.52) | CDK9CCNT1 | |
| SCHEMBL17534997 | 0.74 | DGAT2 (0.37) | CDK9EEDRBBP4SUZ12EZH2 | |
| SCHEMBL17837729 | 0.72 | GRM1 (0.44) | CDK9CCNT1EEDRBBP4SUZ12 | |
| SCHEMBL17837904 | 0.71 | GRM1 (0.42) | CDK9EEDRBBP4SUZ12EZH2 | |
| SCHEMBL17837491 | 0.70 | GRM1 (0.41) | EEDRBBP4SUZ12EZH2GRM5 | |
| SCHEMBL12874666 | 0.70 | GRM1 (0.49) | EEDRBBP4SUZ12EZH2GRM5 | |
| SCHEMBL16967466 | 0.69 | GRM5 (0.43) | CDK9CCNT1EEDRBBP4SUZ12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9328112-B2 | Tetracyclic CDK9 kinase inhibitors | ABBVIE INC. (US) | 2016-05-03 | — | — | US | disclosed |