Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 3/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.36 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.36 |
| ▸ | SSU72 | Q9NP77 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17705271 | 1.00 | LRRK2 (0.41) | LRRK2CYP19A1P2RX4LMNATP53 | |
| SCHEMBL17705272 | 0.88 | TNF (0.37) | CYP19A1P2RX4LMNAPDE4APDE4B | |
| SCHEMBL16294815 | 0.88 | LRRK2 (0.35) | LRRK2CYP19A1P2RX4LMNATP53 | |
| SCHEMBL16293781 | 0.88 | LRRK2 (0.35) | LRRK2CYP19A1P2RX4LMNATP53 | |
| SCHEMBL16293780 | 0.88 | LRRK2 (0.35) | LRRK2CYP19A1P2RX4LMNATP53 | |
| SCHEMBL17705234 | 0.85 | LRRK2 (0.42) | LRRK2CYP19A1P2RX4LMNAL3MBTL1 | |
| SCHEMBL17705285 | 0.84 | LRRK2 (0.44) | LRRK2LMNACCR5ALDH1A1RAB9A | |
| SCHEMBL18892152 | 0.81 | LMNA (0.33) | P2RX4LMNATP53L3MBTL1ALDH1A1 | |
| SCHEMBL18892498 | 0.81 | LMNA (0.33) | P2RX4LMNATP53L3MBTL1ALDH1A1 | |
| SCHEMBL16294814 | 0.79 | CYP19A1 (0.34) | CYP19A1P2RX4PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9657006-B2 | Macrocyclic factor VIIa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-05-23 | — | — | US | disclosed |
| US-20160115159-A1 | MACROCYCLIC FACTOR VIIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160115159-A1 | MACROCYCLIC FACTOR VIIA INHIBITORS | F7, F12, F5 | LRRK2 4310/4885CYP19A1 405/4885P2RX4 4644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.