Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18892502 | 0.92 | LMNA (0.36) | LMNAAPOBEC3AAPOBEC3GALDH1A1MAPT | |
| SCHEMBL17705220 | 0.88 | LMNA (0.49) | LMNAALDH1A1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL17705260 | 0.88 | BRD4 (0.34) | LMNAALDH1A1MAPTP2RX4SMN1; SMN2 | |
| SCHEMBL17705234 | 0.86 | LRRK2 (0.42) | LMNAALDH1A1HTTP2RX4L3MBTL1 | |
| SCHEMBL17705224 | 0.85 | L3MBTL1 (0.39) | LMNAALDH1A1MAPTHTTP2RX4 | |
| SCHEMBL17705269 | 0.82 | LMNA (0.36) | LMNAAPOBEC3AAPOBEC3GALDH1A1MAPT | |
| SCHEMBL18892525 | 0.80 | LMNA (0.47) | LMNAALDH1A1MAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL18892524 | 0.80 | HDAC1 (0.37) | LMNAAPOBEC3AAPOBEC3GALDH1A1MAPT | |
| SCHEMBL17705278 | 0.80 | LMNA (0.41) | LMNAALDH1A1MAPTMAPK1HSD17B10 | |
| SCHEMBL17705251 | 0.79 | LMNA (0.39) | LMNAALDH1A1MAPTSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9657006-B2 | Macrocyclic factor VIIa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-05-23 | — | — | US | disclosed |
| US-20160115159-A1 | MACROCYCLIC FACTOR VIIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160115159-A1 | MACROCYCLIC FACTOR VIIA INHIBITORS | F7, F12, F5 | LMNA 963/4885APOBEC3A 3205/4885APOBEC3G 2681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.