Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 15/20 | 0.47 |
| ▸ | HRH1 | P35367 | 10/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | HTR5A | P47898 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | HTR7 | P34969 | 3/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.35 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3036742 | 0.88 | HTR6 (0.60) | HTR6HRH1MAOAMAOBHTR5A | |
| SCHEMBL13654678 | 0.82 | HTR6 (0.53) | HTR6HRH1MAOAMAOBADRA2A | |
| SCHEMBL3037459 | 0.78 | HTR6 (0.52) | HTR6HRH1MAOAMAOBHTR5A | |
| SCHEMBL2187969 | 0.77 | HTR6 (0.61) | HTR6HRH1MAOAMAOBHTR5A | |
| SCHEMBL3033531 | 0.75 | HTR6 (0.49) | HTR6HRH1HTR5AADRA2AHTR2A | |
| SCHEMBL3024587 | 0.75 | HTR6 (0.59) | HTR6HRH1ADRA2AHTR2AHTR2C | |
| SCHEMBL2185986 | 0.75 | HTR6 (0.57) | HTR6HRH1HTR5AADRA2AHTR2A | |
| SCHEMBL3036548 | 0.75 | HTR6 (0.47) | HTR6HRH1MAOAMAOBHTR5A | |
| SCHEMBL18155286 | 0.74 | HTR6 (0.40) | HTR6HRH1MAOAADRA2ADRD2 | |
| SCHEMBL2188432 | 0.74 | HTR6 (0.46) | HTR6HRH1MAOAMAOBHTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2145887-B1 | SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLES, METHODS FOR THE PRODUCTION AND USE THEREOF | ALLA CHEM LLC (US) | 2016-04-27 | — | — | EP | disclosed |