Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.50 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | USP5 | P45974 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14892785 | 0.85 | EPHX2 (0.68) | EPHX2TRPV4TDP1PKMKMT2A | |
| SCHEMBL14920210 | 0.74 | EPHX2 (0.52) | EPHX2TRPV4HSD11B1TRPM8KCNH2 | |
| SCHEMBL17707658 | 0.72 | EPHX2 (0.76) | EPHX2ALDH1A1CA12CA1CA2 | |
| SCHEMBL17707655 | 0.71 | EPHX2 (0.72) | EPHX2 | |
| SCHEMBL30306676 | 0.68 | EPHX1 (0.49) | EPHX2PKMKMT2AALDH1A1 | |
| SCHEMBL26764345 | 0.68 | EPHX1 (0.49) | EPHX2PKMKMT2AALDH1A1 | |
| SCHEMBL17707670 | 0.67 | EPHX2 (0.72) | EPHX2PKMSMN1; SMN2ALDH1A1 | |
| SCHEMBL16200782 | 0.66 | EPHX2 (0.81) | EPHX2 | |
| SCHEMBL31212421 | 0.66 | TRPV4 (0.68) | TRPV4TDP1KMT2ASMN1; SMN2HSD11B1 | |
| SCHEMBL23390426 | 0.66 | MAPT (0.54) | TRPV4KMT2ASMN1; SMN2TRPM8KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773644-B1 | AZETIDINE COMPOUNDS, COMPOSITIONS AND THEIR USE AS INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE | HOFFMANN LA ROCHE (CH) | 2016-05-04 | — | — | EP | claimed |