Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | TRPV4 | Q9HBA0 | 10/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23850293 | 0.87 | EPHX2 (0.47) | EPHX2TRPV4TRPM8KCNH2ALDH1A1 | |
| SCHEMBL14892785 | 0.81 | EPHX2 (0.68) | EPHX2TRPV4HTT | |
| SCHEMBL22531044 | 0.78 | KMT2A (0.55) | EPHX2ALDH1A1MAPT | |
| SCHEMBL17707671 | 0.74 | EPHX2 (0.50) | EPHX2TRPV4HSD11B1TRPM8KCNH2 | |
| SCHEMBL493523 | 0.73 | ALDH1A1 (0.74) | TRPV4HSD11B1ALDH1A1MAPTTSHR | |
| SCHEMBL3925070 | 0.72 | KMT2A (0.57) | EPHX2TRPV4HSD11B1ALDH1A1CNR1 | |
| SCHEMBL23390426 | 0.72 | MAPT (0.54) | TRPV4TRPM8KCNH2ALDH1A1MAPT | |
| SCHEMBL25301193 | 0.72 | EPHX2 (0.48) | EPHX2TRPV4HSD11B1TSHR | |
| SCHEMBL23850261 | 0.72 | TRPV4 (0.44) | TRPV4ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL29948811 | 0.72 | MAPT (0.54) | TRPV4TRPM8KCNH2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773644-A1 | AZETIDINE COMPOUNDS, COMPOSITIONS AND THEIR USE AS INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE | F.HOFFMANN-LA ROCHE AG (CH) | 2014-09-10 | — | — | EP | claimed |
| WO-2013064467-A1 | AZETIDINE COMPOUNDS, COMPOSITIONS AND THEIR USE AS INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE | F. HOFFMANN-LA ROCHE AG (CH) | 2013-05-10 | — | — | WO | claimed |